The effect of human fibrinolysin on pulmonary metastases of Walker 256 carcinosarcoma.
نویسندگان
چکیده
1. A significant in vitro fibrinolytic activity could be obtained in plasma of rats given human fibrinolysin intravenously. 2. Pulmonary métastaseswere produced in a large percentage (81 per cent) of control rats given inoculations intravenously of 100,000 Walker 256 carcinosarcoma cells/ml. When cells were inoculated into animals with marked fibrinolytic activity produced by human fibrinolysin, the takes of tumor as measured by pulmonary métas tases were markedly reduced to 25 per cent.
منابع مشابه
The effect of hyperlipemia on pulmonary metastases of Walker 256 carcinosarcoma in the rat.
Rats made hyperlipemic by feeding a high fat diet for ~1 days showed increased inhibition of fibrinolysis. Tumor cells injected into these hyperlipemic animals were removed from the circulation rapidly as determined by direct cell counts and subcutaneous injection of blood into weanling animals. Metastases in the lungs occurred much more frequently in hyperlipemic than control animals. This occ...
متن کاملEffect of trypan blue upon distribution of metastases and transplants of rabbit VX2 and Walker rat 256 tumors.
One approach to the study of cancer is the investigation of natural or acquired host defense mechanisms. In 1932 Foulds (6) compared the distribution of intravenous (I.V.) transplants of Brown-Pearce carcinoma in trypan blue-injected rabbits with that in controls. He found an increased incidence of splenic, hepatic, and pulmonary growths in trypan blue-treated animals and suggested that phagocy...
متن کاملThe competitive effect of canavanine on utilization of arginine in growth of Walker carcinosarcoma 256 cells in vitro.
Accordingly, it was of interest to study argininecanavanine relationships in actively multiplying tumor cells. Arginine has been shown to be essen tial for the growth of the Walker carcinosarcoma 256 in vitro (8) ; and, with the recent developments in tissue culture (9, 11) in this laboratory, it was possible to study the effects of canavanine on argi nine metabolism during tumor cell growth. T...
متن کامل18FDG PET/CT in pulmonary carcinosarcoma and brain metastasis
Carcinosarcoma is a rare type of cancer that is composed of a mixture of sarcomatous and carcinomatous elements. Pulmonary carcinosarcoma has a 25% five-year survival rate with a prognosis poorer than other non-small cell lung carcinomas. Herein, we report a case of pulmonary carcinosarcoma and its 18F-FDG PET/CT findings. A 61-year-old male patient presented with brain symptoms, including hea...
متن کاملExperimental studies of factors influencing hepatic metastases. V. Effect of cortisone and adrenalectomy.
The incidence of hepatic metastases in rats subjected to intraportal injection of 5,000 Walker 256 carcinosarcoma cells was similar in rats receiving cortisone and their pair-fed controls. This result was obtained whether cortisone was given prior to, after, or preceding and following the injection of tumor cells. Both cortisone-treated and pair fed control rats exhibited significantly fewer me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 20 شماره
صفحات -
تاریخ انتشار 1960